This formula takes into account the increase in creatinine production with increasing weight, and the decline in creatinine production with age. Estimates glomerular filtration rate based on creatinine and patient characteristics. Use of cockroft and gault formula for estimation of. The cockcroftgault cg formula is provided on this website for research purposes only. The cockroftgault equation typically overestimates creatinine clearance by approximately 10 to 30%. It should not be used for drug dosing or to estimate gfr.
Performance of the cockcroftgault and modification of diet in renal disease equations in estimating gfr in ill hospitalized patients. The best way to determine drug dosing is with the ckdepi creatinine equation 2009 or the mdrd study. The cockcroftgault equation may be inaccurate depending on a patients body weight and bmi. Poggio ed, wang x, greene t, lente f, denis vw, may pm. Alcohol use disorders identification testconcise auditc brief screen to detecting heavy alcohol use alcohol use disorders identification test audit screen for active alcohol abuse or dependence cage questionnaire 4 question screening for alcohol problems car, relax, alone, forget, friends, trouble crafft 2. Performance of the cockcroftgault, mdrd, and new ckdepi.
The best overall index of renal function is considered to be the glomerular filtration rate gfr and a gold standard for its assessment is the renal inulin clearance cin 1,2. Pdf comparison and agreement of the cockroftgault and. This study aims to compare two commonly used formulas for measuring glomerular filtration rate gfr cockcroftgault cg and modification of diet in renal disease mdrd in terms of predicting extent of coronary artery disease cad and short and long. Formula cockcroftgault 140umur x bbkreatini n serum x 72 x 0. The cockcroft gault equation allows the creatinine clearance to be estimated from the serum creatinine in a patient with a stable serum creatinine. Sep 28, 2009 the absolute bias of cockcroft gault was greater in patients with a higher body weight or bmi table 4. The cockcroft gault equation may be inaccurate depending on a patients body weight and bmi.
Carboplatin auc dose calculation calvert formula calculator. Pdf comparison and agreement of the cockroftgault and mdrd. Analysis of the concordance between the estimated values. Estimated gfr values by each formula were compared with measured gfr mgfr by renal inulin clearance in 2208 european adults 46% women, 1. Predictive performance of 12 equations for estimating. Application of cockcroft and gault formula in the community. In the subgroup with lowest body weight, cockcroftgault and ckdepi had a similar accuracy 71. Oct 20, 2008 the cockcroftgault cg and modification of diet in renal disease mdrd formulas are the most commonly used estimations. The carboplatin auc dose calculation provides a formula for calculating the dose based upon a patients glomerular filtration rate and carboplatin target area under the concentration vs time curve. Creatinine clearance rate c cr or crcl is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for. For comparison with the prediction of other formulas, the predicted creatinine clearance by cockcroftgault was normalized per 1. Cockcroftgault equation definition of cockcroftgault. The original cockroftgault equation listed here provides an estimate of creatinine clearance, but this original formula is not adjusted for body surface area and may be less accurate in obese patients. Creatinine clearance estimate by cockcroftgault equation.
The cockcroft and gault formula cg was developed in 1973 using data from 249 men with creatinine clearance ccr from approximately 30 to mlm2. The cockcroft gault cg formula has not been expressed using standardized creatinine values. Prediction of creatinine clearance from serum creatinine. Analysis of the concordance between the estimated values of. Creatinine clearance cockcroftgault equation mdcalc. Cg is no longer recommended for use because it has not been expressed using standardized creatinine values. Calculo filtrado glomerular estimado formula tuchequeo. We used the cockcroftgault formula for several reasons. The prediction of creatinine clearance in mlmin by the cockcroftgault formula was calculated as 140. Ckdepi versus cockcroftgault formula for predicting. Leyvajimenez r, alvarezaguilar c, lopezmolina mg, et al.
Renal function is an indication of the kidneys condition and its role in renal physiology. Also, note that a later study indicates the mdrd may underestimate the actual gfr in healthy patients by up to 29%. In the subgroup with lowest body weight, cockcroft gault and ckdepi had a similar accuracy 71. The absolute bias of cockcroftgault was greater in patients with a higher body weight or bmi table 4. Creatinine clearance is still used as the standard for drug dosing, instead of gfr. Unfortunately, the cin cannot be used routinely in daily practice because of its complexity as a test, and the same is true for other methods using radiolabeled isotopes or nonradioactive contrast agents 35.
The original cockroft gault equation listed here provides an estimate of creatinine clearance, but this original formula is not adjusted for body surface area and may be less accurate in obese patients. The national kidney foundation kdoqi clinical practice guidelines for chronic kidney disease, american journal of kidney disease, 39. Creatinine clearance crcl calculator clinical calculators. This calculator estimates gfr from the cockcroftgault equation.
Glomerular filtration rate gfr describes the flow rate of filtered fluid through the kidney. For women, the formula requires multiplication by 0. Articulo bilingue inglescastellano analysis of the. This calculator uses the 4variable equation from levey 2006, as it.
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